ABSTRACT
Background@#With the advent of the COVID-19 pandemic, pregnant women may turn to online information searches regarding COVID-19 and COVID-19 vaccination. @*Objective@#We aimed to determine global online interest in COVID-19 infection and COVID-19 vaccination in pregnancy. @*Materials and Methods@#We utilized Google Trends data to determine the global search volume index (SVI) for the search terms “COVID-19 in pregnancy” and “COVID vaccine pregnancy” from January 1, 2020, to February 12, 2022, and ranked the top 15 search queries via their individual SVIs to assess the worldwide distribution of interest. Using Pearson correlation, we correlated several economic and pandemic-related country-specific data with the SVIs for the two search terms, while we utilized a one-way analysis of variance to country income groups with the SVIs using ANOVA. Significant correlations were denoted with P < 0.05.@*Results@#SVI for “COVID-19” in pregnancy showed a minimal and nonsignificant downward trend in 2022. SVI for this search term was positively correlated with the SVI for “COVID vaccine pregnancy” (P < 0.05). On the other hand, SVI for “COVID vaccine in pregnancy” showed an exponential decline from November 2020 to 2022. SVI for this search term was also negatively correlated with deaths per 100,000 cases (P < 0.05). Although this was nonsignificant, high-income countries showed higher online interest with the two search terms than low- to low-middle-income countries. There were no significant correlations among specific economic and pandemic-related country-specific data and SVI for both search terms. @*Conclusion@#We observed a constant online interest in COVID-19 in pregnancy during the time period of the study, which may reflect the watchful engagement of people in the absence of face-to-face physician consultations. Peak online interest in COVID-19 vaccine in pregnancy declined steadily, which may reflect either vaccine hesitancy or an increase in public knowledge of COVID-19 vaccines. High-income countries have apparently higher online interest in COVID-19 vaccines, which may be due to access to early mass administration to the general public. These data can be used as a reference regarding future policy-making in the setting of potentially massive public health emergency in the future.